Cell Cycle Control of DNA Replication
and
Genome Stability

It is critical to discover the mechanisms of normal cell cycle regulation if we are to fully understand what goes awry in cancer cells. We are asking how the eukaryotic cell tightly regulates the activity of origins of DNA replication so that the genome is duplicated exactly once per cell cycle.

We use the genetic, molecular, and cell biological tools available in the fruitfly, Drosophila melanogaster, to study the cell cycle regulation and to define DNA damage and the checkpoint responses induced by re-replication in a developmental context.

Our results will have significant and broad impacts for understanding how cancer cells escape apoptosis during genotoxic stress, and the potential of re-replication to cause genome instability and cancer in different cell types.

Copyright ©2007 Syracuse University.
Developed and maintaned by
Shahina B. Maqbool.